The design and synthesis of inhibitors of adenosine 5′-monophosphate deaminase
Copyright policy )The design and synthesis of inhibitors of adenosine 5′-monophosphate deaminase
Carbocylic coformycin (4) is a potent herbicide whose primary mode of action involves inhibition of adenosine 5'-monophosphate deaminase (AMPDA) following phosphorylation of the 5'-hydroxyl group in vivo. The search for more stable and accessible structures led to the synthesis of carbocyclic nebularine (8) and deaminoformycin (10). The latter compound is a good herbicide and its corresponding 5'-monophosphate 14 is a strong inhibitor of plant AMPDA (IC50 100 nM).
Adenosine, Coformycin, Herbicides, Drug Evaluation, Preclinical, Purine Nucleosides, AMP Deaminase, Inhibitory Concentration 50, Structure-Activity Relationship, Adenosine Triphosphate, Drug Design, Ribonucleosides, Enzyme Inhibitors, Phosphorylation, Formycins
Adenosine, Coformycin, Herbicides, Drug Evaluation, Preclinical, Purine Nucleosides, AMP Deaminase, Inhibitory Concentration 50, Structure-Activity Relationship, Adenosine Triphosphate, Drug Design, Ribonucleosides, Enzyme Inhibitors, Phosphorylation, Formycins
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