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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Epilepsiaarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Epilepsia
Article . 1975 . Peer-reviewed
License: Wiley Online Library User Agreement
Data sources: Crossref
Epilepsia
Article . 1975
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Effects of Acute and Chronic Paleocerebellar Stimulation on Experimental Models of Epilepsy in the Cat: Studies with Enflurane, Pentylenetetrazol, Penicillin, and Chloralose

Authors: Kim J. Burchiel; Reginald G. Bickford; James J. Stockard; Robert R. Myers;

Effects of Acute and Chronic Paleocerebellar Stimulation on Experimental Models of Epilepsy in the Cat: Studies with Enflurane, Pentylenetetrazol, Penicillin, and Chloralose

Abstract

SUMMARYEffects of acute and chronic paleocerebellar stimulation were evaluated in four experimental models of epilepsy in 24 adult cats chronically implanted with bilaterally symmetric parasagittal electrocorticographic electrodes and anterior lobe cerebellar stimulation electrodes. Pentylenetetrazol was given intraveneously in 50‐mg increments or 4% enflurane was inspired until grand mal seizures occurred spontaneously or were triggered by photic or auditory stimuli. Alpha‐chloralose, 50 mg/kg, was injected intraperitoneally to produce a model of stimulus‐sensitive myoclonus and sodium penicillin G, 350,000 units/kg, was injected intramuscularly to produce a model of petit mal epilepsy. One‐ to 250‐Hz electrical stimulation of paleocerebellar cortical surfaces was performed with constant‐voltage or constant‐current stimulators at threshold and suprathreshold intensities with average intensities of 8 V and 2.5 mA, respectively. Acute or chronic, threshold or suprathreshold paleocerebellar stimulation did not predictably alter the electrographic or clinical manifestations in any of these four models.RÉSUMÉLa stimulation liminaire ou supraliminaire aigue ou chronique, des lobes cérébelleux antérieurs n'inhibait ni les décharges gpileptiformes sur l'EEG ni les crises cliniques dans quatre modules expgrimentaux d'épilepsie chez le chat. Les quatre modèles étaient: l'injection intraveineux de pentylenetetrazol; l'inhalation d'enflurane 4% jusqu'a là survenue d'une crise grand mal parfois facilitée par la stimulation lumineuse ou par des stimulations sonores; l'injection intrapéritonéale de chloralose pro‐voquant des myoclonies induites par des stimulations sensitives; l'injection intramuscu‐laire de p6nicilline G, produisant une épilepsie de type petit mal.RÉSUMÉNLa estimulación aguda o crónica de los lóbulos cerebelosos anteriores, utilizando estímulos equivalentes o superiores al umbral, no inhibió la actividad epileptiforme en el EEG ni los ataques clínicos en cuatro modelos de epilepsyía en el gato. Los modelos se consig‐uieron mediante el pentilentetrazol intravenoso o la inspiracidn de 4% de enflurane en aire, mantenida hasta que se produjo una convulsión clíhica generalizada. Tambén se utilizó la epilepsía evocada por estímulos auditivós o luminosos, la administración intraperitoneal de cloralosa para producir mioclonus sensible a los estímulos y la penicilina G para crear un modelo de epilipsia de pequen̄o mal.ZUSAMMENFASSUNGDie akute oder chronische Stimulation der vorderen KLeinhirnlappen mit Werten im Bereich der Krampfschwelle oder diese uber‐steigend, verhinderte weder epileptiforme Akti‐vitat im EEG noch manifeste Krämpfe bei 4 Epilepsiemodellen der Katze. Die Epilepsie wurde hervorgerufen durch Pentylentetrazol i.v. oder 4% iges Enfluran als Zumischung zur Einatmungsluft bis ein grösser Krampfanfall ausgelöst wurde; in anderen Fällen wurde er hervorgerufen durch Foto‐oder Tonstimulation, Chloralose i.p. um einen reizempfindlichen Myoklonus hervorzurufen und Penicillin G ijn. um das Modell einer Petit‐Mal‐Epilepsie zu erzeugen.

Keywords

Methyl Ethers, Electroencephalography, Penicillin G, Electric Stimulation, Electrodes, Implanted, Enflurane, Disease Models, Animal, Acoustic Stimulation, Chloralose, Seizures, Cerebellum, Cats, Animals, Pentylenetetrazole, Evoked Potentials

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
32
Average
Top 10%
Top 10%
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