Abstract Sulfide-mineral-bearing mill wastes are sources of high concentrations of acid, soluble metals, and As. These are serious problems for ore mining areas such as the Kemerovo and Cheljabinsk regions in Russia. This study evaluated the distribution of the mill wastes, the mobility of As from the wastes, and the potential of natural materials to attenuate As dispersion in the broader environment. Arsenic contents in wastes of the Belovo Zn-processing (Kemerovo) and the Karabash Cu-smelting plants (Cheljabinsk) are 2–3 orders of magnitude higher than the content of continental crust. Main mineral forms of As in these wastes are arsenopyrite (FeAsS) and scorodite (FeAsO 4 ·2H 2 O). High dissolved As concentrations are found in water draining the wastes and in rivers adjacent to the mill sites. The water concentrations commonly exceed drinking water standards. High As concentrations in bottom sediments of the affected rivers extend a 100 m downstream of the waste drainage input. These sediments are also a source of river water contamination. Experiments were conducted to evaluate the ability of natural water to mobilize As from the wastes. The Belovo tailings released 86% of their contained As to the infiltrating water, whereas the less reactive Karabash tailings released only 22% of total As. The experimental leachates were used as influent to columns that tested the ability of limestone and natural clay to reduce the concentration of dissolved As and associated metals. Some dissolved As was precipitated with Fe, Pb and Sb initially in the limestone column. The decrease in dissolved As is consistent with the accumulation of As in yellow ferriferous sediments in the Belovo settling pond. In the pond and wetland sediments, As mobility is also decreased by the formation of sulfides and arsenides. Cubanite (CuFe 2 S 3 ), klaprothite (Cu 3 BiS 3 ) , rammelsbergite (NiAs 2 ), maucherite (Ni 11 As 8 ), semseyite (Cu 9 Sb 8 S 21 ), and skutterudite (CoAs 3 ) were found in the chemically reducing lower sediments of the Belovo settling pond.