Introduction. On the territory of the Altai territory there are four areas of falling of separating parts of space launch vehicles. For many years, these territories have been exposed to negative factors of rocket and space activities. In order to assess the possible impact of rocket and space activities on the health of the inhabitants of the Altai territory, living near the areas of falling of the separating parts of the launch vehicles, their medical examination is regularly carried out.The aim of the study is to assess the possible impact of rocket and space activities on public health.Materials and methods. Th e results of dynamic analysis of the prevalence of circulatory disease among the residents of Novoaleysky and Ploskovsky village councils of the Tretyakov District of the Altai territory. In 1999, 1929 people were examined, in 2005–1213 people, in 2010–1016 people and in 2015–843 people. Extensive and intensive indicators of prevalence of diseases of the circulatory system were obtained.Results. Basing to results of the dynamic analysis, the peculiarities of the signifi cance and prevalence of the circulatory system diseases, as well as of separate nosologies of this class, were identifi ed. Th e most common circulatory system diseases were determined for the studied contingent. Th e prevalence of this pathology diff ers in men and women. Comparison of the results of the medical examination in 2015 with the data on the general morbidity of the population of the Altai territory showed that the level of detection of diseases of the circulatory system among the inhabitants of the studied areas is signifi cantly higher than the level of the general morbidity of this pathology. Th e obtained results of the analysis of the prevalence of the circulatory system diseases allow overtime monitoring the residents’ health of the territories boarding to the areas of rocket and space activities. Th is allows to evaluate the eff ectiveness of measures to optimize their health and provides sound information for management decisions.Conclusions. Th e overall prevalence of diseases in the study areas in 2015 was signifi cantly lower than in 1999, but the prevalence of diseases of the circulatory system in 2015 was signifi cantly higher than in 1999. In the study areas, the most signifi cant diseases of the circulatory system are hypertension, myocardiodystrophy, angina pectoris and atherosclerosis of the aorta. In all the years studied, the prevalence of circulatory diseases among women was signifi cantly higher than among men. Among women, the prevalence of myocardiodystrophy of various etiologies and hypertension is signifi cantly higher. Th e prevalence of angina in men and women was the same. Th e prevalence of aortic atherosclerosis is much higher in men.