Novel insight into Y‐box binding protein 1 in the regulation of vascular smooth muscle cell proliferation through targeting GC box‐dependent genes
Copyright policy )Novel insight into Y‐box binding protein 1 in the regulation of vascular smooth muscle cell proliferation through targeting GC box‐dependent genes
Abnormal proliferation of vascular smooth muscle cells (VSMCs) is a key event in atherosclerosis and restenosis. In this paper, we report that Y‐box binding protein 1 (YB1) functions as a phenotypic regulator in VSMC proliferation‐differentiation switching through targeting GC box‐dependent genes. Oligo pull‐down assays demonstrated that YB1 binds directly to GC boxes via amino acids 125–220. YB1 C‐terminal tail domain (CTD, amino acids 125–324) regulates GC box‐dependent target gene transcription and suppresses VSMC proliferation. These findings provide a novel insight into the regulation of GC box‐related genes by YB1, and provide a new understanding of VSMC proliferation regulation.
- Hebei University China (People's Republic of)
- Hebei University China (People's Republic of)
- Hebei Medical University China (People's Republic of)
Male, Base Sequence, Transcription, Genetic, Proliferation, Y-box binding protein 1, Oligonucleotides, Cell Differentiation, Tretinoin, Muscle, Smooth, Vascular, GC box, Protein Structure, Tertiary, Rats, Rats, Sprague-Dawley, Phenotype, Vascular smooth muscle cell, Animals, Humans, Y-Box-Binding Protein 1, Nucleotide Motifs, Cell Proliferation
Male, Base Sequence, Transcription, Genetic, Proliferation, Y-box binding protein 1, Oligonucleotides, Cell Differentiation, Tretinoin, Muscle, Smooth, Vascular, GC box, Protein Structure, Tertiary, Rats, Rats, Sprague-Dawley, Phenotype, Vascular smooth muscle cell, Animals, Humans, Y-Box-Binding Protein 1, Nucleotide Motifs, Cell Proliferation
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