Drep-2 is a novel synaptic protein important for learning and memory
Copyright policy )Drep-2 is a novel synaptic protein important for learning and memory
CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal olfactory short- and intermediate-term memory. Drep-2 colocalized with metabotropic glutamate receptors (mGluRs). Chronic pharmacological stimulation of mGluRs compensated for drep-2 learning deficits, and drep-2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in effective mGluR signaling. In fact, Drosophila fragile X protein mutants, shown to benefit from attenuation of mGluR signaling, profited from the elimination of drep-2. Thus, Drep-2 is a novel regulatory synaptic factor, probably intersecting with metabotropic signaling and translational regulation.
- KATHOLIEKE UNIVERSITEIT LEUVEN Belgium
- Max Planck Society Germany
- KU Leuven Belgium
- University of Göttingen Germany
- Freie Universität Berlin Germany
Life Sciences & Biomedicine - Other Topics, metabotropic glutamate receptors, Apoptosis, 0601 Biochemistry and Cell Biology, Receptors, Metabotropic Glutamate, Mass Spectrometry, memory, neuroscience, Fragile X Mental Retardation Protein, synapse, Conditioning, Psychological, Drosophila Proteins, BODY, fragile X syndrome, Biology (General), METABOTROPIC GLUTAMATE-RECEPTOR, Neurons, learning, D. melanogaster, Q, R, CIDE-N protein family, LOCALIZATION, DROSOPHILA-HOMER, Smell, Drosophila melanogaster, Phenotype, Medicine, Drosophila, learning and memory, Life Sciences & Biomedicine, FRAGILE-X, FRAGMENTATION SYSTEM, EXPRESSION, 571, QH301-705.5, Science, Memory, synaptic transmission, Animals, metabotropic glutamate receptor, Biology, Mushroom Bodies, Science & Technology, 42 Health sciences, 31 Biological sciences, ODOR MEMORY, Post-Synaptic Density, 32 Biomedical and clinical sciences, mushroom body, CASPASE-ACTIVATED DNASE, Cardiovascular and Metabolic Diseases, Mutation, Synapses, synapses, EUKARYOTIC TRANSLATION, Neuroscience
Life Sciences & Biomedicine - Other Topics, metabotropic glutamate receptors, Apoptosis, 0601 Biochemistry and Cell Biology, Receptors, Metabotropic Glutamate, Mass Spectrometry, memory, neuroscience, Fragile X Mental Retardation Protein, synapse, Conditioning, Psychological, Drosophila Proteins, BODY, fragile X syndrome, Biology (General), METABOTROPIC GLUTAMATE-RECEPTOR, Neurons, learning, D. melanogaster, Q, R, CIDE-N protein family, LOCALIZATION, DROSOPHILA-HOMER, Smell, Drosophila melanogaster, Phenotype, Medicine, Drosophila, learning and memory, Life Sciences & Biomedicine, FRAGILE-X, FRAGMENTATION SYSTEM, EXPRESSION, 571, QH301-705.5, Science, Memory, synaptic transmission, Animals, metabotropic glutamate receptor, Biology, Mushroom Bodies, Science & Technology, 42 Health sciences, 31 Biological sciences, ODOR MEMORY, Post-Synaptic Density, 32 Biomedical and clinical sciences, mushroom body, CASPASE-ACTIVATED DNASE, Cardiovascular and Metabolic Diseases, Mutation, Synapses, synapses, EUKARYOTIC TRANSLATION, Neuroscience
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