Contribution of selection criteria to genetic interaction types. (A) Hierarchical clustering of GSTF pairs selected on growth-based genetic interaction scores, represented as in Fig. 3. Clustering was performed on the epistatic effects. GSTF pairs marked with a solid circle were also selected based on similarity in DNA binding. Colored branches depict example groups described in the text. (B) Hierarchical clustering of GSTF pairs selected based on similarity in DNA binding, represented as in A. GSTF pairs marked with a solid circle also exhibit a genetic interaction as derived by growth on agar plates [11]. (PDF 339 kb)