Synthesis and Multiple Incorporations of 2′‐O‐Methyl‐5‐hydroxymethylcytidine, 5‐Hydroxymethylcytidine and 5‐Formylcytidine Monomers into RNA Oligonucleotides
Copyright policy )Synthesis and Multiple Incorporations of 2′‐O‐Methyl‐5‐hydroxymethylcytidine, 5‐Hydroxymethylcytidine and 5‐Formylcytidine Monomers into RNA Oligonucleotides
AbstractThe synthesis of 2′‐O‐methyl‐5‐hydroxymethylcytidine (hm5Cm), 5‐hydroxymethylcytidine (hm5C) and 5‐formylcytidine (f5C) phosphoramidite monomers has been developed. Optimisation of mild post‐synthetic deprotection conditions enabled the synthesis of RNA containing all four naturally occurring cytosine modifications (hm5Cm, hm5C, f5C plus 5‐methylcytosine). Given the considerable interest in RNA modifications and epitranscriptomics, the availability of synthetic monomers and RNAs containing these modifications will be valuable for elucidating their biological function(s).
- Cancer Research UK United Kingdom
- University of Cambridge
- UNI: University of Cambridge Cambridge GB United Kingdom
- University Of Cambridge
- University of Cambridge, Cambridge University Library United Kingdom
hydroxymethyl- cytosine, epigenetics, Molecular Structure, formylcytosine, Oligonucleotides, Cytidine, Communications, RNA, methylcytosine, Polyribonucleotides
hydroxymethyl- cytosine, epigenetics, Molecular Structure, formylcytosine, Oligonucleotides, Cytidine, Communications, RNA, methylcytosine, Polyribonucleotides
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