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Molecular Cell
Article . 2022 . Peer-reviewed
License: Elsevier Non-Commercial
Data sources: Crossref
https://pubmed.ncbi.nlm.nih.go...
Article . 2022
Data sources: Europe PubMed Central
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Circling back to PTEN: Fumarate inhibits canonical tumor suppressor

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2022 English Publisher:Elsevier BVJournal:Molecular Cell, volume 82, pages 1,244-1,245 (issn: 1097-2765, Copyright policy )
Authors: Sally E, Claridge; Benjamin D, Hopkins;

doi: 10.1016/j.molcel.2022.03.013

pmid: 35395197

pmc: PMC10311992

Circling back to PTEN: Fumarate inhibits canonical tumor suppressor

Abstract

Ge et al. (2022) describes an inhibitory, post-translational modification of PTEN at C211 by fumarate, which offers new insight into the integration of PI3K signaling and metabolism via a potential feedforward regulatory mechanism involving a PI3K-glucose-fumarate-PTEN axis.

Keywords

Phosphatidylinositol 3-Kinases, Fumarates, PTEN Phosphohydrolase, Proto-Oncogene Proteins c-akt, Signal Transduction

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
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