An Autoimmune Response to Odorant Binding Protein 1a Is Associated with Dry Eye in the Aire-Deficient Mouse
Copyright policy )An Autoimmune Response to Odorant Binding Protein 1a Is Associated with Dry Eye in the Aire-Deficient Mouse
Abstract Sjögren’s Syndrome (SS) is a human autoimmune disease characterized by immune-mediated destruction of the lacrimal and salivary glands. In this study, we show that the Aire-deficient mouse represents a new tool to investigate autoimmune dacryoadenitis and keratoconjunctivitis sicca, features of SS. Previous work in the Aire-deficient mouse suggested a role for α-fodrin, a ubiquitous Ag, in the disease process. Using an unbiased biochemical approach, however, we have identified a novel lacrimal gland autoantigen, odorant binding protein 1a, targeted by the autoimmune response. This novel autoantigen is expressed in the thymus in an Aire-dependent manner. The results from our study suggest that defects in central tolerance may contribute to SS and provide a new and clinically relevant model to investigate the pathogenic mechanisms in lacrimal gland autoimmunity and associated ocular surface sequelae.
- University of California System United States
- THYMUS, INC.
- University of California, San Francisco United States
- Department of Medicine University of California San Diego United States
Male, Mice, Knockout, Mice, Inbred BALB C, Keratoconjunctivitis Sicca, Mice, Nude, AIRE Protein, Mice, SCID, Thymus Gland, Receptors, Odorant, Dacryocystitis, Disease Models, Animal, Mice, Sjogren's Syndrome, Mice, Inbred NOD, Animals, Humans, Dry Eye Syndromes, Female, Autoantibodies, Transcription Factors
Male, Mice, Knockout, Mice, Inbred BALB C, Keratoconjunctivitis Sicca, Mice, Nude, AIRE Protein, Mice, SCID, Thymus Gland, Receptors, Odorant, Dacryocystitis, Disease Models, Animal, Mice, Sjogren's Syndrome, Mice, Inbred NOD, Animals, Humans, Dry Eye Syndromes, Female, Autoantibodies, Transcription Factors
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