Polymorphisms of tryptophan hydroxylase gene and the symptomatology of schizophrenia: an association study
Copyright policy )Polymorphisms of tryptophan hydroxylase gene and the symptomatology of schizophrenia: an association study
Serotonergic neurotransmission may be involved in the etiology of schizophrenia. We systematically searched for human tryptophan hydroxylase (TPH) coding polymorphisms, and detected a novel pentanucleotide repeat deletion polymorphism (GTTTT)4/5 in TPH intron 1b. We also confirmed A779C intron 7. Neither polymorphism showed a significant association with schizophrenia (182 patients with schizophrenia, 148 controls). A significant association, however, between A779C genotypes and the total Manchester Scale (MS) scores was found in male patients (P = 0.045). Subsequently, a significant association was also found between A779C genotypes and the MS negative symptoms scores in male patients (P = 0.030). These results suggest that the TPH gene may play a role in the negative symptoms in male patients with schizophrenia.
Male, Polymorphism, Genetic, Base Sequence, Genotype, Molecular Sequence Data, Restriction Mapping, DNA, Middle Aged, Introns, Gene Frequency, Reference Values, Schizophrenia, Humans, Point Mutation, Female, Schizophrenic Psychology, Alleles, DNA Primers, Repetitive Sequences, Nucleic Acid, Sequence Deletion
Male, Polymorphism, Genetic, Base Sequence, Genotype, Molecular Sequence Data, Restriction Mapping, DNA, Middle Aged, Introns, Gene Frequency, Reference Values, Schizophrenia, Humans, Point Mutation, Female, Schizophrenic Psychology, Alleles, DNA Primers, Repetitive Sequences, Nucleic Acid, Sequence Deletion
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