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A single-nucleotide substitution from C to T at position −1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2003 English Publisher:Springer Science and Business Media LLCJournal:Genes & Immunity, volume 4, pages 528-531 (issn: 1466-4879, eissn: 1476-5470,

Authors: Katsushi Tokunaga; Jun Ohashi; Sornchai Looareesuwan; Izumi Naka; Hathairad Hananantachai; Jintana Patarapotikul;

doi: 10.1038/sj.gene.6364010

pmid: 14551608

A single-nucleotide substitution from C to T at position −1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand

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Abstract

We examined a possible association of single-nucleotide polymorphisms (SNPs) in the promoters of IL-3, IL-4, and IL-13 genes on the 5q31-33, IL-3 -16T>C, IL-4 -590T>C, and IL-13 -1055C>T, with severity of malaria in 361 adult malaria patients in Thailand. The IL-13 -1055T allele showed a significant association with protection from severe malaria (OR 0.51, 95% CI 0.32-0.80; P=0.0032 by the chi(2) test), while allele frequencies of IL-3 -16T>C and IL-4 -590T>C were not statistically different between mild and severe malaria patients. An IL-13 -1055C>T has been reported to alter the regulation of IL-13 production. Thus, IL-13 -1055T may show resistance to severe malaria through the alteration of IL-13 production.

Related Organizations

Mahidol University
Thailand
University of Tokyo
Japan

Keywords

Adult, Interleukin-13, Adolescent, Plasmodium falciparum, Thailand, Polymorphism, Single Nucleotide, Severity of Illness Index, Amino Acid Substitution, Gene Frequency, Odds Ratio, Animals, Humans, Malaria, Falciparum, Promoter Regions, Genetic, Alleles

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