FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens
Copyright policy )FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens
ABSTRACT To determine whether fibroblast growth factor (FGF) has a role in lens development, we have generated transgenic mice expressing a dominant-negative form of the murine FGF receptor-1 (FGFRDN) in the lens. Using the fibre cell- specific αA-crystallin promoter to express the FGFRDN, we have asked whether FGF is required for fibre cell differentiation. The transgenic mice display diminished differentiation of fibre cells as indicated by their reduced elongation. In addition, transgenic lenses have an unusual refractile anomaly that morphological and biochemical data show results from the apoptosis of fibre cells in the central region of the lens. These results show that lens fibre cells are dependent on FGF for their survival and differentiation, and demonstrate that growth factor deprivation in vivo can lead to apoptosis.
- New York University Langone Medical Center United States
Apoptosis, Mice, Transgenic, Refractive Errors, Receptors, Fibroblast Growth Factor, Epithelium, Fibroblast Growth Factors, Mice, Phenotype, Lens, Crystalline, Animals, Signal Transduction
Apoptosis, Mice, Transgenic, Refractive Errors, Receptors, Fibroblast Growth Factor, Epithelium, Fibroblast Growth Factors, Mice, Phenotype, Lens, Crystalline, Animals, Signal Transduction
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