Abstract Silicone-acrylic resin (SAR) was prepared from acrylic monomers and silicone prepolymer by the free radical solution polymerization, and then mixed TiO2 and SiO2 nanoparticles modified by KH570 were added to prepare nanocomposite coating. Thermogravimetric analysis and contact angle measurements showed that the acrylic resin modified by silicone prepolymer exhibited an improved thermostability and a better hydrophobicity compared with the unmodified sample. The adding of nanoparticles further increased the hydrophobicity. The contact angle of modified silicone-acrylic resin with mixed TiO2 and SiO2 nanoparticles of 3 wt% is the highest, 108.4°. The UV resistance and weather resistance of the modified silicone-acrylic resin are significantly improved. It was also found through electrochemical impedance spectroscopy that the corrosion resistance was significantly improved by the addition of mixed TiO2 and SiO2 nanoparticles. Modified silicone-acrylic resin with mixed TiO2 and SiO2 nanoparticles of 3 wt% and 5 wt% coating system maintains an excellent anticorrosion performance (coating resistance Rc of more than 109 Ω cm2) even at 3.5% NaCl electrolyte medium till to 1800 h.