Cell-IQ visualization of motility, cell mass, and osteogenic differentiation of multipotent mesenchymal stromal cells cultured with relief calcium phosphate coating
Copyright policy )Cell-IQ visualization of motility, cell mass, and osteogenic differentiation of multipotent mesenchymal stromal cells cultured with relief calcium phosphate coating
The Cell-IQ continuous surveillance system allowed us to establish the following changes in a 14- day culture in vitro: a twofold suppression of the directional migration of multipotent mesenchymal stromal cells of human adipose tissue (MMSC-AT) towards the samples with a microarc calcium phosphate (CP) coating from synthetic hydroxyapatite; a tenfold decrease in the cell mass on the interphase with the samples, which was accompanied by a slight reduction in the expression of membrane determinants of stromal stem cells; and an enhancement of their osteogenic differentiation (osteocalcin secretion and mineralized matrix formation) on the 21st day of the study. Calcium phosphate particles, but not the calcium and phosphorus ions, may trigger the phenotypic transformation of the MMSC-AT behavior in vitro.
- Tomsk Polytechnic University Russian Federation
- Siberian State Medical University Russian Federation
- Siberian Branch of the Russian Academy of Sciences Russian Federation
- Department of Energy, Engineering, Mechanics and Control Processes Russian Federation
- Russian Academy of Sciences Russian Federation
Calcium Phosphates, Adipose Tissue, Cell Movement, Osteogenesis, Osteocalcin, Humans, Cell Differentiation, Mesenchymal Stem Cells, Cells, Cultured
Calcium Phosphates, Adipose Tissue, Cell Movement, Osteogenesis, Osteocalcin, Humans, Cell Differentiation, Mesenchymal Stem Cells, Cells, Cultured
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