Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
Copyright policy )Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.
- University of California, San Diego United States
- UC San Diego Health System United States
- Howard Hughes Medical Institute United States
- University of California San Diego Medical Center United States
Binding Sites, Receptors, Thyroid Hormone, Base Sequence, Receptors, Retinoic Acid, Recombinant Fusion Proteins, Molecular Sequence Data, Nuclear Proteins, DNA, Ligands, Cell Line, Repressor Proteins, Mice, Gene Expression Regulation, Oligodeoxyribonucleotides, Mutagenesis, Site-Directed, Animals, Humans, Nuclear Receptor Co-Repressor 1, Amino Acid Sequence, Protein Binding
Binding Sites, Receptors, Thyroid Hormone, Base Sequence, Receptors, Retinoic Acid, Recombinant Fusion Proteins, Molecular Sequence Data, Nuclear Proteins, DNA, Ligands, Cell Line, Repressor Proteins, Mice, Gene Expression Regulation, Oligodeoxyribonucleotides, Mutagenesis, Site-Directed, Animals, Humans, Nuclear Receptor Co-Repressor 1, Amino Acid Sequence, Protein Binding
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