Additional file 4: Fig. S4. Transcript cluster analysis of in vitro dataset demonstrates the extent of transcriptional dysregulation by Bin1 KD in primary cultured microglia. (A) Volcano plot of transcript expression following LPS exposure identifies several AD- and DAM-related genes affected by this endotoxin. The color scheme depicted is based on microglial gene co-expression module assignment, as described in Rangaraju et al. [21]. (B) Volcano plot illustrating genes regulated by BIN1 following LPS exposure highlights several inflammatory genes dysregulated by Bin1 siRNA. (C-F) Gene ontology expression analysis identified important cellular functions affected by misexpressed gene clusters.