DIGGER: exploring the functional role of alternative splicing in protein interactions
Copyright policy )DIGGER: exploring the functional role of alternative splicing in protein interactions
Abstract Alternative splicing plays a major role in regulating the functional repertoire of the proteome. However, isoform-specific effects to protein-protein interactions (PPIs) are usually overlooked, making it impossible to judge the functional role of individual exons on a systems biology level. We overcome this barrier by integrating protein-protein interactions, domain-domain interactions and residue-level interactions information to lift exon expression analysis to a network level. Our user-friendly database DIGGER is available at https://exbio.wzw.tum.de/digger and allows users to seamlessly switch between isoform and exon-centric views of the interactome and to extract sub-networks of relevant isoforms, making it an essential resource for studying mechanistic consequences of alternative splicing.
Models, Molecular, Protein Conformation, alpha-Helical, ddc:610, Internet, Binding Sites, Proteome, Computational Biology, Exons, Alternative Splicing, Protein Biosynthesis, Protein Interaction Mapping, Database Issue, Humans, Protein Isoforms, Thermodynamics, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, RNA, Messenger, Databases, Protein, Software, Protein Binding, ddc: ddc:
Models, Molecular, Protein Conformation, alpha-Helical, ddc:610, Internet, Binding Sites, Proteome, Computational Biology, Exons, Alternative Splicing, Protein Biosynthesis, Protein Interaction Mapping, Database Issue, Humans, Protein Isoforms, Thermodynamics, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, RNA, Messenger, Databases, Protein, Software, Protein Binding, ddc: ddc:
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