Pleiohomeotic Interacts with the Core Transcription Elongation Factor Spt5 to Regulate Gene Expression in Drosophila
Copyright policy )Pleiohomeotic Interacts with the Core Transcription Elongation Factor Spt5 to Regulate Gene Expression in Drosophila
The early elongation checkpoint regulated by Positive Transcription Elongation Factor b (P-TEFb) is a critical control point for the expression of many genes. Spt5 interacts directly with RNA polymerase II and has an essential role in establishing this checkpoint, and also for further transcript elongation. Here we demonstrate that Drosophila Spt5 interacts both physically and genetically with the Polycomb Group (PcG) protein Pleiohomeotic (Pho), and the majority of Pho binding sites overlap with Spt5 binding sites across the genome in S2 cells. Our results indicate that Pho can interact with Spt5 to regulate transcription elongation in a gene specific manner.
- UNIVERSITY COLLEGE LONDON, Bartlett School of Planning United Kingdom
- University of Leicester United Kingdom
- University College London United Kingdom
Male, Binding Sites, Chromosomal Proteins, Non-Histone, Science, Q, R, Polycomb-Group Proteins, Genomics, Drosophila melanogaster, Suppression, Genetic, Gene Expression Regulation, Medicine, Animals, Drosophila Proteins, Wings, Animal, Female, Transcriptional Elongation Factors, Research Article, Protein Binding
Male, Binding Sites, Chromosomal Proteins, Non-Histone, Science, Q, R, Polycomb-Group Proteins, Genomics, Drosophila melanogaster, Suppression, Genetic, Gene Expression Regulation, Medicine, Animals, Drosophila Proteins, Wings, Animal, Female, Transcriptional Elongation Factors, Research Article, Protein Binding
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