descriptionPublicationkeyboard_double_arrow_right Article 23 Nov 2020 English Publisher:American Chemical Society (ACS)Journal:Organic Letters, volume 23, pages 13-18 (issn: 1523-7060, eissn: 1523-7052,

Authors: Humberto J. Domínguez; David Cabrera-García; Cristina Cuadrado; Antonello Novelli; M. Teresa Fernández-Sánchez; José J. Fernández; Antonio Hernández Daranas;

doi: 10.1021/acs.orglett.0c03437

pmid: 33226832

handle: 10261/223202

Prorocentroic Acid, a Neuroactive Super-Carbon-Chain Compound from the Dinoflagellate Prorocentrum hoffmannianum

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Abstract

Prorocentroic acid (PA) was isolated from the dinoflagellate Prorocentrum hoffmannianum. Relative configurations for its 35 asymmetric centers were determined by analysis of NMR data including heteronuclear couplings and quantum mechanical calculations. PA was tested by using murine cortical neurons grown on microelectrode arrays. Long-term exposure to subtoxic concentrations induced a significant reorganization of neuronal signaling, mainly by changes in the bursting activity. The observed effects could be due to the activation of a plasticity process.

Related Organizations

University of Barcelona
Spain
Instituto de Productos Naturales y Agrobiología
Spain
Ministry of Economy, Industry and Competitiveness
Spain
University of La Laguna
Spain
Spanish National Research Council
Spain

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Keywords

Magnetic Resonance Spectroscopy, Super-Carbon-Chain, Molecular Structure, Carbon, Prorocentroic acid, Prorocentrum hoffmannianum, Mice, Neuroactive, Dinoflagellida, Animals, Organic Chemicals, Acids

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