Deregulated Ca  2+  cycling underlies the development of arrhythmia and heart disease due to mutant obscurin

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 02 Jun 2017 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Advances, volume 3 (eissn: 2375-2548,

Copyright policy )Funded by:NIH | Interdisciplinary Trainin..., NIH | Stretch-Dependent Calcium..., NSF | REU Site: Integrating Hea... +4 projects

Authors: Li-Yen R. Hu; Maegen A. Ackermann; Peter A. Hecker; Benjamin L. Prosser; Brendan King; Kelly A. O’Connell; Alyssa Grogan; +5 Authors

doi: 10.1126/sciadv.1603081

pmid: 28630914

pmc: PMC5462502

Deregulated Ca 2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin

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Abstract

The goal of this study is to understand how a particular mutation in obscurin proteins leads to congenital heart disease.

Related Organizations

University of Maryland, Baltimore
United States
University of Pennsylvania
United States
James Madison University
United States
University of Maryland School of Medicine
United States

Keywords

Magnetic Resonance Spectroscopy, Heart Diseases, Muscle Proteins, Arrhythmias, Cardiac, Mice, Transgenic, Protein Serine-Threonine Kinases, Disease Models, Animal, Electrocardiography, Mice, Echocardiography, Mutation, Animals, Guanine Nucleotide Exchange Factors, Calcium, Calcium Signaling, Research Articles, Rho Guanine Nucleotide Exchange Factors

9 Research products, page 1 of 1

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