Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily
Copyright policy )Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily
Basigin (Bsg) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Bsg knock‐out mice exhibit infertility of both sexes. Based on limited results, defective implantation has been considered to be the cause of the female infertility. We demonstrate here that disruption of the Bsg gene produces the failure of female reproductive processes including not only implantation but also fertilization. Bsg mRNA expression in cumulus cells and basolateral localization of the Bsg protein in the endometrial epithelium further support the importance of Bsg in these processes.
- Nagoya University Japan
Male, Matrix metalloprotease, Gene Expression, Immunoglobulins, Avian Proteins, Mice, Antigens, CD, Antigens, Neoplasm, Oocyte maturation, Copulation, Animals, Humans, Azoospermia, Mice, Knockout, Membrane Glycoproteins, Ovary, Gene targeting, Blood Proteins, Genitalia, Female, Implantation, Fertilization, Antigens, Surface, Basigin, Female, Infertility, Female, Gene Deletion
Male, Matrix metalloprotease, Gene Expression, Immunoglobulins, Avian Proteins, Mice, Antigens, CD, Antigens, Neoplasm, Oocyte maturation, Copulation, Animals, Humans, Azoospermia, Mice, Knockout, Membrane Glycoproteins, Ovary, Gene targeting, Blood Proteins, Genitalia, Female, Implantation, Fertilization, Antigens, Surface, Basigin, Female, Infertility, Female, Gene Deletion
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).111 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!