Development of B Cell Subsets: Effect of Priming on in Vitro TNP-LPS Responsiveness
Copyright policy )Development of B Cell Subsets: Effect of Priming on in Vitro TNP-LPS Responsiveness
Abstract Mice were injected with DNP-derivatives of thymus-dependent (DNP-OA) and thymus-independent (DNP-Ficoll and TNP-LPS) antigens, and the response to TNP-LPS in vitro was studied after several priming periods. DNP-OA priming decreases the amount of cells responding to TNP-LPS in vitro. In the case of DNP-Ficoll and TNP-LPS-primed cells, there is an initial burst of responsiveness to TNP-LPS, which progressively decreases until an abolishment of TNP-LPS responsiveness is found at day 40 after immunization. The sensitivity to TNP-LPS reappears as new precursor cells differentiate into mature cells. We suggest that B cells progressively gain the capacity to respond to thymus-independent and thymus-dependent antigens (B1-B2 differentiation) and that challenge with a particle antigen increases the ratio of maturation throughtout the pathway.
- Jackson Laboratory United States
Serology: Antigen, Lipopolysaccharides, Male, Ovalbumin, Lymphocyte Activation, Mitomycins, Mice, Tissue Culture:, Animals, Ficoll, Antigens, Antibody-Producing Cells, Crosses, Genetic, Nitrobenzenes, B-Lymphocytes, Unknown:, Strains: C57BL/6, Organs:, Mice, Inbred C57BL, Dinitrobenzenes, Mice, Inbred DBA, Trinitrobenzenes, Female, DBA, Spleen
Serology: Antigen, Lipopolysaccharides, Male, Ovalbumin, Lymphocyte Activation, Mitomycins, Mice, Tissue Culture:, Animals, Ficoll, Antigens, Antibody-Producing Cells, Crosses, Genetic, Nitrobenzenes, B-Lymphocytes, Unknown:, Strains: C57BL/6, Organs:, Mice, Inbred C57BL, Dinitrobenzenes, Mice, Inbred DBA, Trinitrobenzenes, Female, DBA, Spleen
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