Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies

descriptionPublicationkeyboard_double_arrow_right Article 12 Jan 2016 Italy English Publisher:American Chemical Society (ACS)Journal:Journal of Medicinal Chemistry, volume 59, pages 4,245-4,256 (issn: 0022-2623, eissn: 1520-4804,

Copyright policy )Funded by:EC | DRUGPROFILBIND

Authors: Gaspari, Roberto; Rechlin, Chris; Heine, Andreas; Bottegoni, Giovanni; Rocchia, Walter; Schwarz, Daniel; Bomke, Jörg; +3 Authors

doi: 10.1021/acs.jmedchem.5b01643 , 10.5281/zenodo.6484946 , 10.5281/zenodo.6484947

pmid: 26700575

handle: 11576/2688446 , 11585/586989

Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies

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Abstract

Accepted version of the "Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies" paper, DOI: 10.1021/acs.jmedchem.5b01643 Published in the Journal of Medicinal Chemistry of the American Chemical Society

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Italy

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Keywords

Sulfonamides, Molecular Structure, Crystallography, X-Ray, Carbonic Anhydrase II, Kinetics, Zinc, Molecular Medicine; Drug Discovery3003 Pharmaceutical Science, Humans, Hydrophobic and Hydrophilic Interactions, Protein Binding

12 Research products, page 1 of 2

Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (1).
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Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (1).
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BindingDB Entry 50047642: Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies.
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human carbonic anhydrase ii complexed with an inhibitor with a benzenesulfonamide group (5).
2015IsSupplementTo
human carbonic anhydrase ii complexed with an inhibitor with a benzenesulfonamide group (5).
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Carbonic anhydrase 2
2017IsRelatedTo
Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (2).
2015IsRelatedTo
Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (2).
2015IsSupplementTo
Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (3).
2015IsRelatedTo
Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (3).
2015IsSupplementTo

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