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Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 14 Sep 2022Publisher:Research Square Platform LLCJournal:Reproductive Biology and Endocrinology, volume 21 (eissn: 1477-7827, Copyright policy )
Authors: Li Liu; Biting Liu; Lian Wang; Caixia Li; Yang Zhou; Jihui Zhu; Jinye Ding; +2 Authors

doi: 10.21203/rs.3.rs-2047326/v1 , 10.1186/s12958-023-01097-3

pmid: 37194006

pmc: PMC10186293

Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice

Abstract

Abstract Efficient evaluation of the primordial follicle pool (PFP) of mammalian models is an essential subject in biomedical research relating to ovarian physiology and pathogenesis. Our recent study has identified a gene signature including Sohlh1, Nobox, Lhx8, Tbpl2, Stk31, Padi6, and Vrtn strongly correlated with ovarian reserve by using bioinformatics analysis. Aimed to investigate the validity of these candidate biomarkers for evaluating the PFP, we utilized an OR comparison model to decode the relationship between the numbers of PFP and candidate biomarkers in the present study. Our results suggest that these biomarkers Sohlh1, Nobox, Lhx8, Tbpl2, Stk31, Padi6, and Vrtn possess independent potential to evaluate the number of the PFP. And the combination of Sohlh1and Lhx8 can be used as the optimal biomarkers for rapid assessment of the PFP in the murine ovary. Our findings provide a new perspective for evaluating the PFP of the ovary in animal studies and the clinic.

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Keywords

QH471-489, Reproduction, Research, Clinical assessment, Ovary, Gynecology and obstetrics, Mice, Lhx8, Ovarian Follicle, Sohlh1, RG1-991, Basic Helix-Loop-Helix Transcription Factors, Animals, Female, Primordial follicle pool, Biomarkers, Transcription Factors

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    		 3
    popularity
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    		 Top 10%
    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Top 10%
Average
Average
Green
gold