IL-21 signalling via STAT3 primes human naïve B cells to respond to IL-2 to enhance their differentiation into plasmablasts
Copyright policy )IL-21 signalling via STAT3 primes human naïve B cells to respond to IL-2 to enhance their differentiation into plasmablasts
Key PointsIL21-mediated induction of CD25 expression on naïve human B cells requires STAT3. A lack of response to IL-2 may amplify humoral immunodeficiency in patients with STAT3, IL2RG, or IL21R mutations due to unresponsiveness to IL21.
- Manchester University NHS Foundation Trust United Kingdom
- University of Toronto Canada
- National Institute of Allergy and Infectious Diseases United States
- St Vincent's Hospital Sydney Australia
- Necker-Enfants Malades Hospital France
STAT3 Transcription Factor, B-Lymphocytes, Reverse Transcriptase Polymerase Chain Reaction, Interleukins, CD40 Ligand, Plasma Cells, Interleukin-2 Receptor alpha Subunit, Gene Expression, Cell Differentiation, Cell Line, Interleukin-10, Interleukin-21, Mutation, Humans, Interleukin-2, Transcriptome, Cells, Cultured, Cell Proliferation, Oligonucleotide Array Sequence Analysis, Signal Transduction
STAT3 Transcription Factor, B-Lymphocytes, Reverse Transcriptase Polymerase Chain Reaction, Interleukins, CD40 Ligand, Plasma Cells, Interleukin-2 Receptor alpha Subunit, Gene Expression, Cell Differentiation, Cell Line, Interleukin-10, Interleukin-21, Mutation, Humans, Interleukin-2, Transcriptome, Cells, Cultured, Cell Proliferation, Oligonucleotide Array Sequence Analysis, Signal Transduction
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