The Transcriptional Landscape of the Mammalian Genome
Copyright policy )The Transcriptional Landscape of the Mammalian Genome
This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5′ and 3′ boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
- University of Michigan–Flint United States
- University Federico II of Naples Italy
- National Institutes of Health United States
- Karolinska Institute Sweden
- National Research Council Italy
Identification, 060102 Bioinformatics, DNA, Complementary, RNA, Untranslated, Mouse, 060114 Systems Biology, 572, Transcriptomis, Transcription, Genetic, Bioinformatics, Annotation, RNA Splicing, Regulatory Sequences, Ribonucleic Acid, Sequences, 230203 Statistical Theory, 060407 Genome Structure and Regulation, Mice, 360100 Political Science, Animals, Humans, Gene-expression, 270202 Genome Structure, Promoter Regions, Genetic, Arrays, 3' Untranslated Regions, Conserved Sequence, Terminator Regions, Genetic, Genome, Base Sequence, Genome, Human, Proteins, Genomics, 06 Biological Sciences, Human-chromosome-21, Rnas, Multidisciplinary Sciences, RNA, CX, Transcription Initiation Site
Identification, 060102 Bioinformatics, DNA, Complementary, RNA, Untranslated, Mouse, 060114 Systems Biology, 572, Transcriptomis, Transcription, Genetic, Bioinformatics, Annotation, RNA Splicing, Regulatory Sequences, Ribonucleic Acid, Sequences, 230203 Statistical Theory, 060407 Genome Structure and Regulation, Mice, 360100 Political Science, Animals, Humans, Gene-expression, 270202 Genome Structure, Promoter Regions, Genetic, Arrays, 3' Untranslated Regions, Conserved Sequence, Terminator Regions, Genetic, Genome, Base Sequence, Genome, Human, Proteins, Genomics, 06 Biological Sciences, Human-chromosome-21, Rnas, Multidisciplinary Sciences, RNA, CX, Transcription Initiation Site
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