CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF
Copyright policy )CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF
CD30 is a surface marker for neoplastic cells of Hodgkin's lymphoma and shows sequence homology to members of the tumor necrosis factor (TNF) receptor superfamily. Using a chimeric probe consisting of the extracellular domain of CD30 fused to truncated immunoglobulin heavy chains, we expression cloned the cDNA cognate from the murine T cell clone 7B9. The encoded protein is a 239 amino acid type II membrane protein whose C-terminal domain shows significant homology to TNF alpha, TNF beta, and the CD40L. Cross-hybridization to an induced peripheral blood T cell cDNA library yielded the human homolog, which is 72% identical at the amino acid level. The recombinant human ligand enhances the proliferation of CD3-activated T cells yet induces differential responses, including cell death, in several CD30+ lymphoma-derived clones. The human and murine genes map to 9q33 and the proximal region of chromosome 4, respectively.
- Boston Children's Hospital United States
Membrane Glycoproteins, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Chromosome Mapping, Ki-1 Antigen, Ligands, Binding, Competitive, Hodgkin Disease, Recombinant Proteins, Mice, Inbred C57BL, Mice, Antigens, CD, Antigens, Neoplasm, Biomarkers, Tumor, Animals, Cytokines, Humans, Amino Acid Sequence, CD30 Ligand
Membrane Glycoproteins, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Chromosome Mapping, Ki-1 Antigen, Ligands, Binding, Competitive, Hodgkin Disease, Recombinant Proteins, Mice, Inbred C57BL, Mice, Antigens, CD, Antigens, Neoplasm, Biomarkers, Tumor, Animals, Cytokines, Humans, Amino Acid Sequence, CD30 Ligand
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).537 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 0.1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!