Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity
Copyright policy )Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity
Prolactin (PRL) and vasoactive intestinal polypeptide (VIP) mRNA levels were elevated in the brainstem of neuronal nitric oxide synthase (nNOS) gene knockout (KO) mice compared to the levels in nNOS control mice. In addition, PRL mRNA levels increased in the hypothalamus and the brainstem of nNOS control mice after administration of 7-nitro-indazole (7-NI), a relatively selective nNOS inhibitor. The results suggest that NO inhibits PRL. No differences in the genes measured were observed in inducible NOS KO mice.
- Washington State University United States
- Washington State University United States
Male, Mice, Knockout, Indazoles, Hypothalamus, Nerve Tissue Proteins, Nitric Oxide Synthase Type I, Prolactin, Mice, Inbred C57BL, Mice, Gene Expression Regulation, Animals, RNA, Messenger, Nitric Oxide Synthase, Brain Stem, Vasoactive Intestinal Peptide
Male, Mice, Knockout, Indazoles, Hypothalamus, Nerve Tissue Proteins, Nitric Oxide Synthase Type I, Prolactin, Mice, Inbred C57BL, Mice, Gene Expression Regulation, Animals, RNA, Messenger, Nitric Oxide Synthase, Brain Stem, Vasoactive Intestinal Peptide
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