Signalling pathways involved in multisite phosphorylation of the transcription factor ATF‐2
Copyright policy )Signalling pathways involved in multisite phosphorylation of the transcription factor ATF‐2
The multisite phosphorylation of the transcription factor ATF‐2 was investigated using transformed embryonic fibroblasts from wild‐type mice and mice deficient in c‐Jun N‐terminal kinases (JNK)1 and 2, and in the presence and absence of inhibitors of p38 mitogen‐activated protein kinase (p38 MAPK) and the classical MAP kinase cascade. In wild‐type cells, p38 MAPK and extracellular signal‐regulated protein kinase (ERK)1/2 were not rate limiting for the phosphorylation of Thr69, Thr71 or Ser90. In JNK‐deficient cells, p38 MAPK substituted for JNK partially in the phosphorylation of Thr69 and p38 MAPK or ERK1/2 in the phosphorylation of Thr71. JNK was the only MAP kinase that phosphorylated Ser90 under the conditions examined.
- University of Massachusetts Medical School United States
- University of Massachusetts System United States
- Medical Research Council United Kingdom
- MRC Protein Phosphorylation and Ubiquitylation Unit United Kingdom
- University of Dundee United Kingdom
Phosphopeptides, activating transcription factor-2, ATF-2, MAP Kinase Kinase 7, cyclic AMP-response element, Mice, Enzyme Inhibitors, Phosphorylation, Cyclic AMP Response Element-Binding Protein, c-Jun N-terminal kinase, Mice, Knockout, /dk/atira/pure/subjectarea/asjc/1300/1303, E1A, name=Biochemistry, CRE, ERK, epidermal growth factor, Tetradecanoylphorbol Acetate, Mitogen-Activated Protein Kinases, extracellular signal-regulated protein kinase, /dk/atira/pure/subjectarea/asjc/1300/1307, /dk/atira/pure/subjectarea/asjc/1300/1304, Anisomycin, Signal Transduction, /dk/atira/pure/subjectarea/asjc/1300/1311, /dk/atira/pure/subjectarea/asjc/1300/1312, MAP Kinase Signaling System, name=Genetics, early adenovirus protein 1A, 610, p38, name=Cell Biology, activating protein 1, Animals, Mitogen-Activated Protein Kinase 8, GST, name=Biophysics, /dk/atira/pure/subjectarea/asjc/1300/1315, EGF, glutathione S-transferase, Mitogen-Activated Protein Kinase Kinases, Activating Transcription Factor 2, Epidermal growth factor, 500, name=Molecular Biology, Fibroblasts, AP-1, Embryo, Mammalian, Peptide Fragments, name=Structural Biology, Extracellular signal-regulated protein kinase, Tumour necrosis factor, Transcription Factors
Phosphopeptides, activating transcription factor-2, ATF-2, MAP Kinase Kinase 7, cyclic AMP-response element, Mice, Enzyme Inhibitors, Phosphorylation, Cyclic AMP Response Element-Binding Protein, c-Jun N-terminal kinase, Mice, Knockout, /dk/atira/pure/subjectarea/asjc/1300/1303, E1A, name=Biochemistry, CRE, ERK, epidermal growth factor, Tetradecanoylphorbol Acetate, Mitogen-Activated Protein Kinases, extracellular signal-regulated protein kinase, /dk/atira/pure/subjectarea/asjc/1300/1307, /dk/atira/pure/subjectarea/asjc/1300/1304, Anisomycin, Signal Transduction, /dk/atira/pure/subjectarea/asjc/1300/1311, /dk/atira/pure/subjectarea/asjc/1300/1312, MAP Kinase Signaling System, name=Genetics, early adenovirus protein 1A, 610, p38, name=Cell Biology, activating protein 1, Animals, Mitogen-Activated Protein Kinase 8, GST, name=Biophysics, /dk/atira/pure/subjectarea/asjc/1300/1315, EGF, glutathione S-transferase, Mitogen-Activated Protein Kinase Kinases, Activating Transcription Factor 2, Epidermal growth factor, 500, name=Molecular Biology, Fibroblasts, AP-1, Embryo, Mammalian, Peptide Fragments, name=Structural Biology, Extracellular signal-regulated protein kinase, Tumour necrosis factor, Transcription Factors
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