Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2
Copyright policy )Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2
Embryonic Stem Cells not only hold a lot of potential for use in regenerative medicine, but also provide an elegant and efficient way to study specific developmental processes and pathways in mammals when whole animal gene knock out experiments fail. We have investigated a pathway through which HDAC1 affects cardiovascular and more specifically cardiomyocyte differentiation in ES cells by controlling expression of SOX17 and BMP2 during early differentiation. This data explains current discrepancies in the role of HDAC1 in cardiovascular differentiation and sheds light into a new pathway through which ES cells determine cardiovascular cell fate.
- Northwestern University United States
- Northeastern University United States
- Northwestern University United States
- Northwestern University Medical School United States
Time Factors, Science, Bone Morphogenetic Protein 2, Fluorescent Antibody Technique, Gene Expression, Histone Deacetylase 1, Cell Line, Mice, HMGB Proteins, SOXF Transcription Factors, Animals, Myocytes, Cardiac, Embryoid Bodies, Embryonic Stem Cells, Models, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Q, R, Cell Differentiation, Mice, Inbred C57BL, Gene Knockdown Techniques, Medicine, Research Article, Signal Transduction
Time Factors, Science, Bone Morphogenetic Protein 2, Fluorescent Antibody Technique, Gene Expression, Histone Deacetylase 1, Cell Line, Mice, HMGB Proteins, SOXF Transcription Factors, Animals, Myocytes, Cardiac, Embryoid Bodies, Embryonic Stem Cells, Models, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Q, R, Cell Differentiation, Mice, Inbred C57BL, Gene Knockdown Techniques, Medicine, Research Article, Signal Transduction
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).17 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!