<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Case-control study and meta-analysis of low density lipoprotein receptor-related protein gene exon 3 polymorphism in Alzheimer's disease

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2001Publisher:Elsevier BVJournal:Neuroscience Letters, volume 316, pages 17-20 (issn: 0304-3940,

Authors: Jon Infante; Carlos Fernández-Viadero; Javier Llorca; Marisa Sánchez-Guerra; Onofre Combarros; Ana Fontalba; Jose L. Fernandez-Luna; +2 Authors

doi: 10.1016/s0304-3940(01)02342-4

pmid: 11720768

Case-control study and meta-analysis of low density lipoprotein receptor-related protein gene exon 3 polymorphism in Alzheimer's disease

- Summary
- Subjects
- Related research
  (8)
- Metrics

Abstract

The low density lipoprotein receptor-related protein (LRP) may influence both the clearance and the production of beta-amyloid peptide and thus plays a role in Alzheimer's disease (AD) pathogenesis. Previous studies, although inconsistent, have suggested that the LRP exon 3 CC genotype contributes to the risk of AD. A case-control study utilizing a clinically well-defined group of 305 sporadic AD patients and 304 control subjects was performed to test this association in an ethnically homogeneous population from Spain. In the current study, the LRP CC genotype was not over-represented in AD patients compared to non-demented controls. A meta-analysis of previous studies revealed a weak correlation of LRP CC genotype with AD (odds ratio of 1.35, P=0.01).

Related Organizations

University of Cantabria
Spain
Marqués de Valdecilla University Hospital
Spain

Keywords

Aged, 80 and over, Male, Polymorphism, Genetic, Genotype, Exons, Middle Aged, Gene Frequency, Alzheimer Disease, Case-Control Studies, Humans, Female, Low Density Lipoprotein Receptor-Related Protein-1, Aged

8 Research products, page 1 of 1

FP2860
2017IsRelatedTo
LRP protein
2017IsRelatedTo
Low density lipoprotein-related protein 1 variant
2017IsRelatedTo
LRP1 protein
2017IsRelatedTo
Alpha-2 macroglobulin receptor
2017IsRelatedTo
Alternative protein LRP1
2017IsRelatedTo
Prolow-density lipoprotein receptor-related protein 1
2017IsRelatedTo
LRP1 protein
2017IsRelatedTo

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	44
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%