Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice
Copyright policy )Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice
Significance Neutralizing antibodies are important for immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and as therapeutics for the prevention and treatment of COVID-19. We identified high-affinity nanobodies against SARS-CoV-2 receptor-binding domain and found that nanobody cocktails consisting of two noncompeting nanobodies were able to block ACE2 engagement with RBD variants present in human populations and potently neutralize both wild-type SARS-CoV-2 and the N501Y D614G variant at low concentrations. Prophylactic administration of nanobody cocktails reduced viral loads in mice infected with the N501Y D614G SARS-CoV-2 virus, showing that nanobody cocktails are useful as prophylactic agents against SARS-CoV-2.
- Monash University Australia
- UNSW Sydney Australia
- Monash University, Clayton campus Australia
- Walter and Eliza Hall Institute of Medical Research Australia
- Australian Research Council Australia
SARS-CoV-2, 610, COVID-19, Biological Sciences, Single-Domain Antibodies, Antibodies, Viral, Antibodies, Neutralizing, COVID-19 Drug Treatment, Mice, Animals, Humans, Angiotensin-Converting Enzyme 2, Camelids, New World
SARS-CoV-2, 610, COVID-19, Biological Sciences, Single-Domain Antibodies, Antibodies, Viral, Antibodies, Neutralizing, COVID-19 Drug Treatment, Mice, Animals, Humans, Angiotensin-Converting Enzyme 2, Camelids, New World
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