Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan
Copyright policy )Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan
Beta-amyloid (Aβ) deposition in brain accumulates as a function of age in people with Down syndrome (DS) with subsequent development into Alzheimer disease neuropathology, typically by 40 years of age. In vivo imaging using the Pittsburgh compound B (PiB) ligand has facilitated studies linking Aβ, cognition, and dementia in DS. However, there are no studies of PiB binding across the lifespan in DS. The current study describes in vitro 3H-PiB binding in the frontal cortex of autopsy cases with DS compared to non-DS controls. Tissue from 64 cases included controls (n = 25) and DS (n = 39). In DS, 3H-PiB binding was significantly associated with age. After age 40 years in DS, 3H-PiB binding rose dramatically along with increasing individual variability. 3H-PiB binding correlated with the amount of Aβ42. Using fixed frontal tissue and fluorescent 6-CN-PiB, neuritic and cored plaques along with extensive cerebral amyloid angiopathy showed 6-CN-PiB binding. These results suggest that cortical PiB binding as shown by positron emission tomography imaging reflects plaques and cerebral amyloid angiopathy in DS brain.
- University of California, Irvine United States
- University of Kentucky HealthCare United States
- University of California, San Francisco United States
- University of Kentucky United States
- Markey Cancer Center United States
Male, Aging, Trisomy 21, Biological Psychology, Neurodegenerative, Beta-amyloid, Alzheimer's Disease, Ligands, Cognition, H-3-X-34, Psychology, 2.1 Biological and endogenous factors, Child, Aniline Compounds, Middle Aged, (3)H-X-34, Frontal Lobe, Plaques, Child, Preschool, Neurological, Thioflavine S, Biomedical Imaging, Female, Autopsy, Alzheimer disease, Protein Binding, Neurofibrillary tangles, Adult, Adolescent, Intellectual and Developmental Disabilities (IDD), 1.1 Normal biological development and functioning, Clinical Sciences, 610, Young Adult, Acquired Cognitive Impairment, Humans, Preschool, Aged, Neurology & Neurosurgery, Amyloid beta-Peptides, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Infant, Brain Disorders, Thiazoles, Cerebral Amyloid Angiopathy, Positron-Emission Tomography, Biological psychology, Dementia, Down Syndrome
Male, Aging, Trisomy 21, Biological Psychology, Neurodegenerative, Beta-amyloid, Alzheimer's Disease, Ligands, Cognition, H-3-X-34, Psychology, 2.1 Biological and endogenous factors, Child, Aniline Compounds, Middle Aged, (3)H-X-34, Frontal Lobe, Plaques, Child, Preschool, Neurological, Thioflavine S, Biomedical Imaging, Female, Autopsy, Alzheimer disease, Protein Binding, Neurofibrillary tangles, Adult, Adolescent, Intellectual and Developmental Disabilities (IDD), 1.1 Normal biological development and functioning, Clinical Sciences, 610, Young Adult, Acquired Cognitive Impairment, Humans, Preschool, Aged, Neurology & Neurosurgery, Amyloid beta-Peptides, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Infant, Brain Disorders, Thiazoles, Cerebral Amyloid Angiopathy, Positron-Emission Tomography, Biological psychology, Dementia, Down Syndrome
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