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Suppression of α-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-α autocrine/paracrine signaling

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 15 Feb 2021 English Publisher:American Society for Cell Biology (ASCB)Journal:Molecular Biology of the Cell, volume 32, pages 348-361 (issn: 1059-1524, eissn: 1939-4586,

Copyright policy )Funded by:NIH | Quantitative Analysis of ..., NIH | TRAINING IN SIGNAL TRANSD..., NIH | Opera Phenix High Through... +3 projects

Authors: Douglas A. Chapnick; Graycen Wheeler; Eric Bunker; Xuedong Liu;

doi: 10.1091/mbc.e19-08-0474

pmid: 33378218

pmc: PMC8098817

Suppression of α-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-α autocrine/paracrine signaling

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Abstract

The loss of adherens junctions elevates autocrine TGF-α signaling in a TACE-dependent manner. Keratinocyte epithelial sheets depend on this signaling to propagate ERK activity for proliferation and motility signaling.

Related Organizations

University of Colorado Boulder
United States
University of Colorado System
United States
University of California System
United States
UNIVERSITY OF COLORADO
University of Colorado Health
United States

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Keywords

Epidermal Growth Factor, Epithelial Cells, Articles, Adherens Junctions, ADAM17 Protein, Transforming Growth Factor alpha, ErbB Receptors, Cell Movement, Cell Line, Tumor, Paracrine Communication, Metalloproteases, HaCaT Cells, Humans, Phosphorylation, alpha Catenin, Cell Proliferation, Signal Transduction

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