Killer immunoglobulin‐like receptors (KIR2DL2 and/or KIR2DS2) in presence of their ligand (HLA‐C1 group) protect against chronic myeloid leukaemia
Copyright policy )Killer immunoglobulin‐like receptors (KIR2DL2 and/or KIR2DS2) in presence of their ligand (HLA‐C1 group) protect against chronic myeloid leukaemia
AbstractWe have analysed the frequency of killer immunoglobulin‐like receptors (KIR) in cohorts of patients from Turkey with acute lymphocyte leukaemia (n = 52), acute myeloid leukaemia (n = 54) and chronic myeloid leukaemia (CML) (n = 52) and compared the results with 154 controls. We also examined the frequencies of human leucocyte antigen (HLA)‐C groups, ‐Bw4, ‐Bw6 and where appropriate the combination of the KIR gene and its ligand. We found several statistically significant results between the patients and the controls. We proposed a model in CML of protection via KIR2DL2 and/or KIR2DS2 with the presence of the ligand HLA‐C1 group and susceptibility via HLA‐Bw4 homozygosity (i.e. absence of HLA‐Bw6).
- UNIVERSITE DE TOULOUSE France
- Belfast City Hospital United Kingdom
- University of Liverpool United Kingdom
- University of California, San Francisco United States
- Belfast Health and Social Care Trust United Kingdom
Adult, Male, Adolescent, Genotype, HLA-C Antigens, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Cohort Studies, Leukemia, Myeloid, Acute, Young Adult, Gene Frequency, Receptors, KIR, Child, Preschool, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Receptors, KIR2DL2, Humans, Female, Genetic Predisposition to Disease, Child, Aged
Adult, Male, Adolescent, Genotype, HLA-C Antigens, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Cohort Studies, Leukemia, Myeloid, Acute, Young Adult, Gene Frequency, Receptors, KIR, Child, Preschool, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Receptors, KIR2DL2, Humans, Female, Genetic Predisposition to Disease, Child, Aged
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