Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine
Copyright policy )Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine
The mouse small intestinal epithelium consists of four principal cell types deriving from one multipotent stem cell: enterocytes, goblet, enteroendocrine, and Paneth cells. Previous studies showed that Math1 , a basic helix-loop-helix (bHLH) transcription factor, is expressed in the gut. We find that loss of Math1 leads to depletion of goblet, enteroendocrine, and Paneth cells without affecting enterocytes. Colocalization of Math1 with Ki-67 in some proliferating cells suggests that secretory cells (goblet, enteroendocrine, and Paneth cells) arise from a common progenitor that expresses Math1 , whereas absorptive cells (enterocytes) arise from a progenitor that is Math1 -independent. The continuous rapid renewal of these cells makes the intestinal epithelium a model system for the study of stem cell regeneration and lineage commitment.
- Baylor College of Medicine United States
- Howard Hughes Medical Institute United States
Homeodomain Proteins, Heterozygote, Paneth Cells, Enteroendocrine Cells, Helix-Loop-Helix Motifs, Gene Expression, Membrane Proteins, Cell Differentiation, Mice, Enterocytes, Ki-67 Antigen, Intestine, Small, Basic Helix-Loop-Helix Transcription Factors, Animals, Cell Lineage, Goblet Cells, Intestine, Large, Intestinal Mucosa, Alleles, Cell Division
Homeodomain Proteins, Heterozygote, Paneth Cells, Enteroendocrine Cells, Helix-Loop-Helix Motifs, Gene Expression, Membrane Proteins, Cell Differentiation, Mice, Enterocytes, Ki-67 Antigen, Intestine, Small, Basic Helix-Loop-Helix Transcription Factors, Animals, Cell Lineage, Goblet Cells, Intestine, Large, Intestinal Mucosa, Alleles, Cell Division
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