Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip
Copyright policy )Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip
Blood lipids are important cardiovascular disease (CVD) risk factors with both genetic and environmental determinants. The Whitehall II study (n=5592) was genotyped with the gene-centric HumanCVD BeadChip (Illumina). We identified 195 SNPs in 16 genes/regions associated with 3 major lipid fractions and 2 apolipoprotein components at p12,500) revealed previously unreported associations of SH2B3 (p1 mmol/L in LDL cholesterol [approximately 1 SD of the trait distribution]). These data suggest that multiple common alleles of small effect can make important contributions to individual differences in blood lipids potentially relevant to the assessment of CVD risk. These genes provide further insights into lipid metabolism and the likely effects of modifying the encoded targets therapeutically.
- Malmö University Sweden
- University of Bristol United Kingdom
- University of Glasgow United Kingdom
- University of London United Kingdom
- National Institute of Health Pakistan
Adult, Male, 2716 Genetics (clinical), HDL, European Continental Ancestry Group, 610, Polymorphism, Single Nucleotide, LDL, Cohort Studies, Apolipoproteins E, 1311 Genetics, Risk Factors, 616, Genetics, Humans, Genetics(clinical), Computer Simulation, Polymorphism, Triglycerides, Alleles, Apolipoproteins A, Probability, Apolipoproteins B, Genetics & Heredity, Apolipoprotein A-I, Cholesterol, HDL, Genetic Variation, Single Nucleotide, Cholesterol, LDL, Middle Aged, Lipids, Cholesterol, Apolipoproteins, Apolipoprotein A-V, Cardiovascular Diseases, Female
Adult, Male, 2716 Genetics (clinical), HDL, European Continental Ancestry Group, 610, Polymorphism, Single Nucleotide, LDL, Cohort Studies, Apolipoproteins E, 1311 Genetics, Risk Factors, 616, Genetics, Humans, Genetics(clinical), Computer Simulation, Polymorphism, Triglycerides, Alleles, Apolipoproteins A, Probability, Apolipoproteins B, Genetics & Heredity, Apolipoprotein A-I, Cholesterol, HDL, Genetic Variation, Single Nucleotide, Cholesterol, LDL, Middle Aged, Lipids, Cholesterol, Apolipoproteins, Apolipoprotein A-V, Cardiovascular Diseases, Female
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