This document presents the state of work in the WP4 of the CS3MESH4EOSC project on integrating user-level applications and usage scenarios within the ScienceMesh federation. The CS3MESH4EOSC consortium is building a federated mesh of sync & share systems (EFSS) and applications focused on scientific and research use-cases, referred to as ScienceMesh. The Interoperability Platform (IOP) worked out in WP3 provides the technical basis for the federation, ensuring compatibility across sync & share products, enabling data flow and user information exchange as well as implementing communication for application workflows. The partner-provided deployments of sync & share systems at federated sites provide the testing and pre-production environments for the federation. Finally, management procedures and tools developed by WP2 constitute the operational basis for the federation. Within WP4, a set of user-level applications is being developed with the aim of being embedded into this federated mesh of sync & share systems. This work is organized in four application-related design, development and testing tasks (T4.1-T4.4) as well as two auxiliary tasks (T4.5-T4.6). This deliverable provides the summary of the work within WP4 related to the integration of the flagship applications identified for the ScienceMesh. It provides an overview of the state of the demonstrators prepared within the first 18 months of the Project. It also summarizes the status of work in the auxiliary tasks dedicated to ensuring that requirements and other information flow among WP4 and WP3, WP4 and WP2, while analysing the future sustainability of those Project results.