Downregulation of miR‐638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC
Copyright policy )Downregulation of miR‐638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC
Aberrant expression of microRNAs has been shown to regulate the biological processes of lung cancer cells. However, the role of miR‐638 in the development of NSCLC is still unclear. In this study, low miR‐638 and high SOX2 were shown to be associated with tumor size and metastasis of NSCLC patients. Downregulated miR‐638 could promote cell invasion and proliferation, while high miR‐638 expression reversed the effect. Furthermore, miR‐638 could regulate SOX2 by directly binding to its 3′‐UTR. Silencing of SOX2 by siRNA partially abolished the enhancement of cell invasion and proliferation induced by downregulated miR‐638. Aberrant miR‐638 expression could modulate the expression levels of markers of epithelial‐to‐mesenchymal transition. Our results indicate that miR‐638 may play a pivotal role in the development of NSCLC.
- Nanjing Medical University China (People's Republic of)
- Jiangsu Province Hospital China (People's Republic of)
Male, Epithelial-Mesenchymal Transition, Lung Neoplasms, miR-638, Proliferation, Down-Regulation, SRY (sex determining region Y)-box 2, Apoptosis, Invasion, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Humans, Neoplasm Invasiveness, 3' Untranslated Regions, Cell Proliferation, Binding Sites, Base Sequence, SOXB1 Transcription Factors, Middle Aged, Gene Expression Regulation, Neoplastic, MicroRNAs, Epithelial-to-mesenchymal transition, Female, RNA Interference, Non-small-cell lung cancer
Male, Epithelial-Mesenchymal Transition, Lung Neoplasms, miR-638, Proliferation, Down-Regulation, SRY (sex determining region Y)-box 2, Apoptosis, Invasion, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Humans, Neoplasm Invasiveness, 3' Untranslated Regions, Cell Proliferation, Binding Sites, Base Sequence, SOXB1 Transcription Factors, Middle Aged, Gene Expression Regulation, Neoplastic, MicroRNAs, Epithelial-to-mesenchymal transition, Female, RNA Interference, Non-small-cell lung cancer
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