Background & Aims: The prognosis of colorectal cancer (CRC) varies considerably, and there is a compelling need to identify novel biomarkers with prognostic significance. The aim of the present study was to evaluate the prognostic value of a panel of six genes (CDH1, SMAD3, TGFβ1, ICAM-1, TIMP-1 and MUC12) in CRC patients.Methods. We evaluated these genes by qRT-PCR in normal and CRC tumor tissue, and correlated the relative gene expression values with clinical, pathological aspects and other biological factors.Results. RNA expression levels of CDH1, SMAD3, TGFβ1, ICAM-1, TIMP-1 and MUC12 were measured by qRT-PCR in a set of 39 tumor samples and non-cancer tissue. Statistically significant increases in expression levels were found for ICAM-1 and TIMP-1 when comparing tumor samples to the non-tumor group.Conclusions. Among the genes which displayed differential expressions between tumor tissue and adjoining normal tissue, the ones that presented statistically significant correlations were TIMP-1 and SMAD3, possibly with prognostic significance.Abbreviations: CDH1: E-cadherin; CRC: colorectal cancer; E-cadherin: CDH1; EMT: epithelial-mesenchymal transition; IBD: inflammatory bowel disease; ICAM-1: Intercellular Adhesion Molecule 1; MMPs: matrix metalloproteinases; MUC12: Mucin 12, Cell Surface Associated; OS: overall survival; SMAD3: SMAD Family Member; TGFß1: Transforming growth factor beta 1; TIMP-1: tissue inhibitor of metalloproteinase-1.