Guilty until proven innocent: the case of NPC1 and cholesterol
Copyright policy )Guilty until proven innocent: the case of NPC1 and cholesterol
Cholesterol accumulation in the endosomes and lysosomes of Niemann-Pick C (NPC) cells is considered to be the hallmark of this disorder, so the main focus of NPC research has revolved around cholesterol and its role in disease pathogenesis. However, recent data indicate that cholesterol is not the primary culprit in this human lipidosis. I propose a new hypothesis for the potential action or function of the NPC1 protein in the endosome. In this context, the relationship of NPC2 and NPC1 is also discussed.
- Icahn School of Medicine at Mount Sinai United States
Niemann-Pick Diseases, Cholesterol, Membrane Glycoproteins, Models, Chemical, Niemann-Pick C1 Protein, Intracellular Signaling Peptides and Proteins, Humans, Carrier Proteins
Niemann-Pick Diseases, Cholesterol, Membrane Glycoproteins, Models, Chemical, Niemann-Pick C1 Protein, Intracellular Signaling Peptides and Proteins, Humans, Carrier Proteins
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