Decapping enzymes STOP “cancer” ribosomes in their tracks
Copyright policy )Decapping enzymes STOP “cancer” ribosomes in their tracks
The production of ribosomes plays a central role in regulating cell cycle progression and cancer proliferation. A new study by Gaviraghi et al (2018) shows that mRNA decapping coactivator PNRC1 acts as a tumor suppressor by regulating ribosome biogenesis. PNRC1 relocalizes the Dcp1/Dcp2 mRNA decapping complex to the nucleolus and promotes decapping of specific snoRNAs to disrupt the processing of ribosomal RNA. By slowing rRNA processing, and thus ribosome biogenesis, PNRC1 acts as a gatekeeper that restrains oncogenic potential.
- University of California, San Francisco United States
Ribosomal, Biological Sciences, Medical and Health Sciences, RNA, Ribosomal, Information and Computing Sciences, Neoplasms, Endoribonucleases, Genetics, RNA, Humans, Ribosomes, Cancer, Developmental Biology
Ribosomal, Biological Sciences, Medical and Health Sciences, RNA, Ribosomal, Information and Computing Sciences, Neoplasms, Endoribonucleases, Genetics, RNA, Humans, Ribosomes, Cancer, Developmental Biology
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).7 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!