<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

α-2,8-sialyltransferase is involved in the development of multidrug resistance via PI3K/Akt pathway in human chronic myeloid leukemia

Effect of α-2,8-Sialyltransferase and MDR in CML

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2015 English Publisher:WileyJournal:IUBMB Life, volume 67, pages 77-87 (issn: 1521-6543,

Authors: Li Jia; Huimin Zhou; Hongshuai Li; Ning Wang; Weijie Dong; Xu Zhang; Xiaoyan Miao;

doi: 10.1002/iub.1351

pmid: 25855199

α-2,8-sialyltransferase is involved in the development of multidrug resistance via PI3K/Akt pathway in human chronic myeloid leukemia

- Summary
- Subjects
- Related research
  (4)
- Metrics

Abstract

Cell surface sialylation is emerging as an important feature of cancer cell multidrug resistance (MDR). We have focused on the influence of 2,8-sialyltransferases in key steps of the development of MDR in chronic myeloid leukemia (CML). The expressional profiles of six α-2,8-sialyltransferases were generated in three pairs of CML cell lines and peripheral blood mononuclear cells (PBMC) of CML patients. Cellular MDR phenotype positively correlated with ST8SIA4 and ST8SIA6 levels. Furthermore, ST8SIA4 mediated the activity of phosphoinositide-3 kinase (PI3K)/Akt signal pathway and the expression of P-glycoprotein (P-gp). Targeting the PI3K/Akt pathway by its specific inhibitor LY294002, or by Akt RNA interfering reversed the MDR phenotype of K562/ADR cells. Inhibition of PI3K/Akt pathway also attenuated the effects caused by the overexpression of ST8SIA4 on MDR. Therefore this study indicated that α-2,8-sialyltransferases involved in the development of MDR of CML cells probably through ST8SIA4 regulating the activity of PI3K/Akt signaling and the expression of P-gp.

Related Organizations

Dalian Medical University
China (People's Republic of)

Keywords

Adult, Male, Adolescent, Gene Expression Regulation, Leukemic, Mice, Nude, Middle Aged, Xenograft Model Antitumor Assays, Drug Resistance, Multiple, Sialyltransferases, Phosphatidylinositol 3-Kinases, Young Adult, Drug Resistance, Neoplasm, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Animals, Humans, Female, Proto-Oncogene Proteins c-akt, Aged

4 Research products, page 1 of 1

Alpha-2,8-sialyltransferase
2017IsRelatedTo
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
2017IsRelatedTo
Alpha-2,8-sialyltransferase 8F
2017IsRelatedTo
Alpha-2,8-sialyltransferase 8F variant 1
2017IsRelatedTo

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	43
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%