The state ofperipheral blood circulation of lower extremities after repeated osteoperforations was conducted in experiment (28 dogs) and in clinic (24 patients with chronic ischemic disease) using modern methods. It was shown that simple and low invasive surgical intervention for the creation of multiple reparative regeneration and reactive hyperemia foci provides stable improvement of regional hemodynamic and tissue metabolism both in compensated and decompensated disturbances of blood circulation in extremities.