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Genetics
Article . 1993 . Peer-reviewed
License: OUP Standard Publication Reuse
Data sources: Crossref
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Genetics
Article
Data sources: UnpayWall
Genetics
Article . 1993
Data sources: Europe PubMed Central
Genetics
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Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus.

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1993 English Publisher:Oxford University Press (OUP)Journal:Genetics, volume 134, pages 243-249 (eissn: 1943-2631, Copyright policy )
Authors: A C Christensen; B Gordesky-Gold; Douglas R. Dorer; G Harries; M A Cadden;

doi: 10.1093/genetics/134.1.243

pmid: 8514133

pmc: PMC1205427

Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus.

Abstract

Abstract One of the most extreme examples of gene dosage sensitivity is the Triplo-lethal locus (Tpl) on the third chromosome of Drosophila melanogaster, which is lethal when present in either one or three copies. Increased dosage of an unlinked locus, Isis, suppresses the triplo-lethal phenotype of Tpl, but not the haplo-lethal phenotype. We have mapped Isis to the X chromosome region 7E3-8A5, and shown that the suppression is a gene dosage effect. Altered dosage of Isis in the presence of two copies of Tpl has no obvious effects. By examining the interactions between Isis dosage and Tpl we suggest that Isis does not directly repress Tpl expression, but acts downstream on the triplo-lethal phenotype of Tpl.

Related Organizations
Keywords

Male, X Chromosome, Genetic Linkage, Chromosome Mapping, Trisomy, Translocation, Genetic, Drosophila melanogaster, Phenotype, Suppression, Genetic, Multigene Family, Y Chromosome, Mutation, Animals, Female, Genes, Lethal

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
6
Average
Average
Average
hybrid