Circulating Total and Active Metalloproteinase‐9 and Tissue Inhibitor of Metalloproteinases‐1 in Patients with Systemic Lupus Erythomatosus
Copyright policy )Circulating Total and Active Metalloproteinase‐9 and Tissue Inhibitor of Metalloproteinases‐1 in Patients with Systemic Lupus Erythomatosus
We investigated the serum concentration of total metalloproteinase‐9 (tMPP‐9), active MMP‐9 (aMMP‐9), and tissue inhibitor of metalloproteinase‐1 (TIMP‐1) in a group of 41 patients with SLE and 20 healthy controls. Serum levels of tMMP‐9 and TIMP‐1 were assessed by an enzyme‐linked immunosorbent assay (ELISA) and aMMP‐9 by fluorometric assay. The tMMP‐9 level was lower in SLE patients (mean 262 ng/mL) than in healthy volunteers (mean 325 ng/mL) (P = .048). Similarly, aMMP‐9 level was lower in SLE patients (mean 121 ng/mL) than in control group (mean 169 ng/mL) (P = .0355) and lower in active SLE (mean 54 ng/mL) than in inactive disease (mean 99 ng/mL) (P = .033). TIMP‐1 level was also lower in SLE patients (mean 181 ng/mL) than in control group (mean 233 ng/mL) (P = .004). In SLE patients, a positive correlation was found between tMMP‐9 and aMMP‐9 (ρ = 0.568; P = .001). We also found a positive correlation of tMMP‐9 and TIMP‐1 with VEGF concentrations (ρ = 0.450, P = .005 and ρ = 0.387; P = .018, resp). tMMP‐9, aMMP‐9, and TIMP‐1 serum levels are lower in SLE patients than in healthy control group.
- UNIVERSYTET MEDYCZNY W LODZI. Poland
- Copernicus Memorial Hospital Poland
- University of Łódź Poland
- Uniwersytet Łódzki (University of Lodz) Poland
- Uniwersytet Medyczny w Łodzi Poland
Adult, Male, Vascular Endothelial Growth Factor A, Tissue Inhibitor of Metalloproteinase-1, Adolescent, Middle Aged, Research Communication, Gene Expression Regulation, Matrix Metalloproteinase 9, Case-Control Studies, Pathology, RB1-214, Humans, Lupus Erythematosus, Systemic, Female, Aged
Adult, Male, Vascular Endothelial Growth Factor A, Tissue Inhibitor of Metalloproteinase-1, Adolescent, Middle Aged, Research Communication, Gene Expression Regulation, Matrix Metalloproteinase 9, Case-Control Studies, Pathology, RB1-214, Humans, Lupus Erythematosus, Systemic, Female, Aged
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