UAP56- a key player with surprisingly diverse roles in pre-mRNA splicing and nuclear export
Copyright policy )UAP56- a key player with surprisingly diverse roles in pre-mRNA splicing and nuclear export
Transcripts contain introns that are usually removed from premessenger RNA (MRNA) in the process of pre-mRNA splicing. After splicing, the mature RNA is exported from the nucleus to the cytoplasm. The splicing and export processes are coupled. UAP56 protein, which is ubiquitously present in organisms from yeasts to humans, is a DExD/H-box family RNA helicase that is an essential splicing factor with various functions in the prespliceosome assembly and mature spliceosome assembly. Collective evidence indicates that UAP56 has an essential role in mRNA nuclear export. This mini-review summarizes recent evidence for the role of UAP56 in pre-mRNA splicing and nuclear export.
- Gwangju Institute of Science and Technology Korea (Republic of)
DEAD-box RNA Helicases, RNA Splicing, Active Transport, Cell Nucleus, Humans, Models, Biological
DEAD-box RNA Helicases, RNA Splicing, Active Transport, Cell Nucleus, Humans, Models, Biological
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