ATG16L1 T300A polymorphism and Crohn’s disease susceptibility: evidence from 13,022 cases and 17,532 controls
Copyright policy )ATG16L1 T300A polymorphism and Crohn’s disease susceptibility: evidence from 13,022 cases and 17,532 controls
Many studies have reported the association between the autophagy-related 16-like 1 gene (ATG16L1) T300A polymorphism (rs2241880) and Crohn's disease (CD) susceptibility, but the results were inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 24 studies including 13,022 cases and 17,532 controls were included in this meta-analysis. Logistic regression analysis indicated that the ATG16L1 T300A polymorphism was associated with CD risk in Caucasians (P < 0.01). The pooled estimations of OR(1) (GG vs. AA) and OR(2) (GA vs. AA) in Caucasian studies by Bayesian meta-analysis method was [1.87, 95% confidence interval (CI) 1.69-2.05] and (1.39, 95% CI 1.27-1.51), respectively. The mode of heritance of the G allele was most likely to be co-dominant in Caucasians. However, no significant association was found in Asians. This meta-analysis suggests that the G allele of ATG16L1 T300A is a low-penetrant gene for developing CD in Caucasians.
- Second Military Medical University China (People's Republic of)
- Southern Medical University China (People's Republic of)
- Wenzhou Medical University China (People's Republic of)
- Changhai Hospital China (People's Republic of)
- Guangxi Medical University China (People's Republic of)
Genotype, Inheritance Patterns, Autophagy-Related Proteins, Polymorphism, Single Nucleotide, White People, Genetics, Population, Logistic Models, Crohn Disease, Case-Control Studies, Humans, Genetic Predisposition to Disease, Carrier Proteins, Alleles
Genotype, Inheritance Patterns, Autophagy-Related Proteins, Polymorphism, Single Nucleotide, White People, Genetics, Population, Logistic Models, Crohn Disease, Case-Control Studies, Humans, Genetic Predisposition to Disease, Carrier Proteins, Alleles
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