descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1992 English Publisher:WileyJournal:Arthritis & Rheumatism, volume 35, pages 95-100 (issn: 0004-3591, eissn: 1529-0131,

Authors: Yutaka Okano; Thomas A. Medsger; Virginia D. Steen;

doi: 10.1002/art.1780350114

pmid: 1731817

Autoantibody to U3 Nucleolar Ribonucleoprotein (Fibrillarin) In Patients with Systemic Sclerosis

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Abstract

AbstractTo determine the clinical significance of serum antibodies to the U3 small nuclear ribonucleoprotein particle ([U3]snRNP), we studied sera from 416 patients with systemic sclerosis (SSc) and 264 controls, using immunofluorescence and immunoprecipitation assays. The presence of serum anti‐(U3)snRNP was highly specific to SSc, was found more frequently in blacks, and was associated with skeletal muscle disease and primary pulmonary arterial hypertension. These antibodies may identify one or more unusual clinical subsets of SSc.

Related Organizations

University of Pittsburgh
United States

Keywords

Adult, Male, Scleroderma, Systemic, Chromosomal Proteins, Non-Histone, Hypertension, Pulmonary, Racial Groups, Fluorescent Antibody Technique, Middle Aged, Precipitin Tests, Cross-Sectional Studies, Humans, Female, Musculoskeletal Diseases, Autoantibodies

3 Research products, page 1 of 1

rRNA 2'-O-methyltransferase fibrillarin
2017IsRelatedTo
Uncharacterized protein
2017IsRelatedTo
rRNA 2'-O-methyltransferase fibrillarin
2017IsRelatedTo

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